Macrocycles in Drug Discovery

By Jeremy Levin (Editor), David Rotella (Editor), David Newman (Contribution by), Karl Heinz Altmann (Contribution by), A Ganesan (Contribution by), Anders Poulsen (Contribution by), Michael Burnet (Contribution by), Wieslaw Kazmierski (Contribution by), David Fairlie (Contribution by), Daniel Obrecht (Contribution by), Eric Feyfant (Contribution by), Alan Mathiowetz (Contribution by), Mark Peterson (Contribution by)

A variety of macrocycles have become important drugs or have been identified as leads to marketed drugs. This text will discuss these compounds, their pharmacology and synthesis, in the context of their broad chemotype as compounds composed of large rings. Providing a wide reaching review of this important area in a single volume, this book will be of interest to biochemists, pharmaceutical scientists and medicinal chemists working in industry or academia.


"The book is a wellmade snapshot of current research, describing development stories of established macrocycle drugs and their properties, as well as new avenues in their development."

"The book s 11 chapters, written by distinguished experts, are mostly dedicated to macrocycles for a specific protein target or target class."

"Numerous examples presented along with the compounds potency, selectivity, permeability, bioavailability and other properties allow the reader to understand which determinants make a successful macrocyclic drug."--Christian Heinis "Chemistry World ""


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About the Hardcover

Publisher Not available
Publish date 10/16/2014
Pages 528
ISBN-13 9781849737012
ISBN-10 1849737010
Language English

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